Hepatosplenomegaly associated with chronic malaria exposure: evidence for a pro-inflammatory mechanism exacerbated by schistosomiasis

Hepatosplenomegaly associated with chronic malaria exposure: evidence for a pro-inflammatory mechanism exacerbated by schistosomiasis

In sub-Saharan Africa, chronic hepatosplenomegaly, with palpable firm/hard organ consistency, is common, particularly among school-aged children. This morbidity can be caused by long-term exposure to malaria, or by Schistosoma mansoni, and it is exacerbated when these two occur together. Although immunological mechanisms probably underlie the pathogenic process, these mechanisms have not been i...

Chronic Hepatosplenomegaly in African School Children: A Common but Neglected Morbidity Associated with Schistosomiasis and Malaria

Chronic hepatosplenomegaly, which is known to have a complex aetiology, is common amongst children who reside in rural areas of sub-Saharan Africa. Two of the more common infectious agents of hepatosplenomegaly amongst these children are malarial infections and schistosomiasis. The historical view of hepatosplenomegaly associated with schistosomiasis is that it is caused by gross periportal fib...

Oxidative DNA Damage and Pro-inflammatory Response In Chronic Exposure To Cement Dust

Angiostatin overexpression is associated with an improvement in chronic kidney injury by an anti-inflammatory mechanism.

Angiostatin, a proteolytic fragment of plasminogen, is a potent anti-angiogenic factor recently shown also to have an inhibitory effect on leukocyte recruitment and macrophage migration. Because both angiogenesis and inflammation play key roles in the progression of chronic kidney disease, we evaluated the effect of angiostatin treatment in the rat remnant kidney model. Rats were pretreated for...

P-63: Chronic Exposure to Gly-Phosate; Evidence for Testicular Toxicity and Sperm Parameters

Background: Glyphosate (GPT) is a broad-spectrum systemic herbicide used to kill weeds, especially annual broadleaf and grasses known to compete with commercial crops grown around the globe. According to United States environmental protection agency the chemical has been reported as a third class toxin. Present study was designed in order to evaluate GPT-induced detrimental effects on testicula...